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Impaired Brain Drainage by the Glymphatic System Due to Dental Problems Can Trigger Brain Diseases

Manfred Doepp*

Holistic Center, 13 Haupt St., 9030 Abtwil, Switzerland

*Corresponding author

Manfred Doepp, Holistic Center, 13 Haupt St., 9030 Abtwil, Switzerland

Abstract

Usually the oral area is not taken into consideration when brain diseases exist. However, toxins in the mouth are a burden for the lymphatic system of the head and consequently for the glymphatic system of the brain. So, the brain cannot detoxify itself sufficiently. Most important are foci called NICO = non-infectious-chronic-osteolysis in the jawbone. If they are detected and removed, the situation of the brain (e.g. dementia) will improve. What we all need is a toxin-free mouth.

Keywords: Brain Diseases, Brain Drainage, Glymphatic System, Dental Problems.

Introduction

At present, we are experiencing increasingly frequent brain problems. These also have to do with coagulation disorders and reduced blood flow caused by Covid-19 viruses and their spike proteins. What is usually neglected are the problems caused by toxins in the mouth area and the resulting problems with the lymphatic drainage of the head and neck in the context of stress on the glymphatic system of the brain.

The glymphatic system is a disposal system for waste products in the central nervous system of vertebrates, i.e. in the brain and spinal cord. The name is a neologism of the terms glia and lymphatic system and was introduced by a research group led by Maiken Nedergaard (Rochester and Copenhagen) in 2012 [1-4].  In addition to the lymphatic system, which ends outside the meninges, i.e. does not occur in the CNS, the glymphatic system acts as a flowing circulation system for the removal of brain metabolic end products and toxins.

Important dentogenic toxins

  1. A) Metals, i.e. heavy metals in amalgam (e.g. mercury) and dental gold (e.g. palladium), light metals like titanium in implants.
  2. B) Chronic bacterial inflammation of the gingiva and gums, especially gangrenous pulp, pulpitis, granuloma findings.
  3. C) Jaw bone foci in the sense of non-infectious chronic ostitis (NICO, FDOC).
  4. D) Periodontitis and gum pockets filled with problematic pathogens.
  5. E) Root canal treatments fail their goal in 80%. Dead tissues remain.

Effects

As a result of these disorders, the brain cannot detoxify itself sufficiently and accumulates toxins. Different brain diseases can be triggered depending on the individual's previous exposure. In the preliminary stages, there is the phenomenon of "brain fog" with symptoms such as dizziness, concentration problems and fatigue. After intensive dental diagnostics with computer tomography, we have regularly found dentogenic findings. Additionally ultrasound is used. We found improvements in symptoms after treatment. These examinations should be carried out in all cases where there are unclear brain-related problems.

NICO = non-infectious-chronic-osteolysis

The most important dentogenic problems are NICO = FDOC: non-infectious-chronic-osteolysis. NICOs take place in the jawbone [5-9]. These are areas in the bone filled with fatty tissue [10,11]. You can hardly see them in the usual X-ray, but in CT and with special ultrasound. A suspicion can be examined and confirmed by determining the “Rantes” value in the blood [12-14].

Results and Conclusion

Resulting diseases
NICOs can cause serious diseases: On the one hand cancer (especially breast cancer), on the other hand dementia and Alzheimer's due to the stress on the glymphatic system and afterwards toxins accumulation in the brain, often combined with autoaggressive inflammation of the glia. Abnormal proteins (e.g. Tau-) will follow. Surgical elimination of NICO foci is absolutely necessary. Even more: a mouth without toxins is necessary. Dentists should take this into consideration [15-18].

Conclusion
We have seen
a) normalizations of tumor markers,
b) normalizations of the RANTES values, and
c) improvements of dementia after removals of the NICOs.

Hence, the oral area is decisive for health of the brain. A toxin-free mouth must be achieved. Then the glymphatic system can detoxify the brain.

REFERENCES

  1. Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, et al. (2022) The glymphatic system: Current understanding and modeling. in science 25(9): 104987.
  2. Lauren M Hablitz, Maiken Nedergaard (2021) The glymphatic system, Curr Biol 20: R 1371-R1375.
  3. Rasmussen MK, Mestre H, Nedergaard M (2022) Fluid Transport in the Brain. In: Physiological Reviews. 102: 1025-1151.
  4. Terhi J Lohela, Tuomas O Lilius, Maiken Nedergaard (2022) The glymphatic system: implications for drugs for central nervous system diseases, Nat Rev Drug Discov 21(10): 763-779.
  5. Bouquot JE, Roberts AM, Person P, Christian J (1992) NICO (neuralgia-inducing cavitational osteonecrosis): osteomyelitis in 224 jawbone samples from patients with facial neuralgia. Oral Surg Oral Med Oral Pathol 73 :307-319.
  6. Bouquot JE, Christian J (1995) Longterm effects of jawbone curettage on the pain of facial neuralgia. J Oral Maxillofac Surg 53 : 387-397.
  7. Bouquot JE, Roberts A (1992) NICO (neuralgia-inducing cavitational osteonecrosis): radiographic appearance of the „invisible“ osteomyelitis. Oral Surg Oral Med Oral Pathol 74: 600
  8. Lechner J Herd (1993) Regulation und Information – Störfelder im Zahn-, Mund- und Kieferbereich; HÜTHIG Verlag Heidelberg, first edition.
  9. Lechner J (2010) Störfelder im Trigeminusbereich und Systemerkrankungen: Ein systemisches Sanierungskonzept für Zahn-Störfelder, Verlag für Ganzheitliche Medizin 1999 Lechner, J. NICO – Ist fehlende röntgenologische Evidenz Beweis fehlender klinischer Existenz? 578-592.
  10. Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A (1996) Springer MS: Cloning, expression, and characterization of the human eosinophil eotaxin receptor. In: J. Exp. Med. 183. Jahrgang, Nr. 5, Mai pp. 2349–2354.
  11. Struyf S, Menten P, Lenaerts JP, Put W, D’Haese A, et al. (2001) Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. In: Eur. J. Immunol 31(7): 2170–2178.
  12. Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, et al. (2003) Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages. In: Biochim. Biophys. Acta. 1617. year, 1(2): 80–88.
  13. Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, et al. (2001) The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity. In: J. Biol. Chem. 276. pp. 10620–10626.
  14. Ignatov A, Robert J, Gregory-Evans C, Schaller HC (2006) RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. In: Br. J. Pharmacol. 149(5): 490–497.
  15. Doepp, Manfred Topic: Mouth, Teeth, and Dentition; Journal of Advances in Bioengineering and Biomedical Science Research (ISSN: 2640-4133), 5(3): 186- 187.
  16. Doepp Manfred (2022) Significant Findings in Tooth Roots and Jaw Bones Can Cause Serious Diseases. Clinical Research and Clinical Trials. 6(1).
  17. Doepp, Manfred MD (2022) Could Dentistry Be a Major Factor in Human Poisonings? IOSR Journal of Dental and Medical Sciences, (IOSR-JDMS) 21(03): 48-49.
  18. Doepp Manfred (2021) Our Brains are Targets No. 1, Cleared for Firing - an Overview. American Journal of Biomedical Science & Research. 14(3).

JCMCRI
ISSN: 3064-8025

Journal of Clinical & Medical Case Reports, Images (JCMCRI) ISSN: 3064-8025 is a peer-reviewed journal dedicated to publishing clinical images from all sectors of medicine. The goal of this magazine is to disseminate information about new discoveries and treatments in science and medicine.

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